Screening of all donors for anti-neutrophil or anti-HLA antibodies. … Use of pre-storage leukoreduced blood. … Appropriate utilization of blood products.

How do you manage TRALI?

Current management of TRALI consists of respiratory and circulatory support based on clinical severity. Oxygen supplementation is required in almost all patients; in severe cases, mechanical ventilation may be necessary. Hypotensive episodes can be treated with pressors.

What are risk factors for TRALI?

Conclusions: The risk factors for TRALI in this study included Number of transfusions and FFP units were positively correlated with TRALI. Age, female sex, tobacco use, chronic alcohol abuse, positive fluid balance, shock before transfusion, ASA score and mechanical ventilation may be potential risk factors for TRALI.