Receptor activator of nuclear factor kappa-Β ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a protein that in humans is encoded by the TNFSF11 …

What is RANKL in osteoporosis?

The interaction of RANK with its ligand (RANKL) has been identified as the final common pathway through which bone resorption is regulated [29]. By binding to its receptor RANK on osteoclastic precursors, RANKL controls the differentiation, proliferation, and survival of osteoclasts.

What are the nutrition side effects of rank inhibitors?

The trace element strontium has the dual effects of preventing bone resorption and promoting bone formation. Studies have shown that strontium mainly functions through the OPG/RANK/RANKL signaling pathway, resulting in decreased bone resorption (Mi et al., 2017).