A cryostat is a machine that maintains the cryogenic temperature of samples or devices placed inside it. … Cryostats use a number of refrigeration methods to achieve low temperatures, such as a helium bath with liquid helium or liquid nitrogen. Other cryogenic fluids are argon, oxygen, and nitrogen.

What are the advantages of cryostat?

The advantage of cryostat-cut frozen section is the preservation of cell density and tissue architecture, which is most important in the diagnosis of neurosurgical materials, especially in case of diffusely infiltrating glioma.

What is the difference between cryostat and microtome?

What is a Cryostat? Similar to a standard microtome, a cryostat functions to obtain thin (1-10 mm in thickness) sections from a piece of tissue, but while a standard microtome carries the operation at room temperature, the cryostat enables the operator to section the tissue at low temperature (–20 to –30 C).