The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. … This form of the enzyme helps control the levels of certain hormones. In the brain, catechol-O-methyltransferase helps break down certain chemical messengers called neurotransmitters.

What is the function of COMT?

COMT is involved in catabolizing catecholamines such as dopamine. These neurotransmitters appear to be involved in regulating mood which can contribute to aggression. The most common gene variant studied in the COMT gene is the Valine (Val) to Methionine (Met) substitution at codon 158.

What is the COMT gene and how does it affect your health?

The COMT gene provides instructions for making an enzyme called catechol-O-methyltransferase. An estimated 20-30% of Caucasians of European ancestry have a COMT gene variation which limits the body’s ability to remove catechols (a specific type of molecule that includes dopamine, norepinephrine, estrogen, etc.)