However, individuals with large platelets may have an increased risk for thrombotic complications because some genetic traits share an association with an increased MPV and a higher risk for cardiovascular disease.

What are unusually large platelets called?

Hematology. Giant platelet disorders, also known as macrothrombocytopenia, are rare disorders featuring abnormally large platelets, thrombocytopenia and a tendency to bleeding. Giant platelets cannot stick adequately to an injured blood vessel walls, resulting in abnormal bleeding when injured.

Can leukemia cause giant platelets?

In addition to the circulating blasts compatible with acute myeloid leukemia (AML), the peripheral blood is notable for immature megakaryocytes and giant platelets.