Refrigerate SIMPONI at 36°F to 46°F (2°C to 8°C). If needed, you may store SIMPONI at room temperature up to 77°F (25°C) for one period of time up to 30 days. Write the date of that you remove SIMPONI from the refrigerator on the carton. If SIMPONI has reached room temperature, do not put it back in the refrigerator.

How long can you leave SIMPONI out of the fridge?

If needed, store SIMPONI® at room temperature, up to 77° F (25°C) for one period of time up to 30 days. Do not return it to the refrigerator. Throw away if not used within 30 days at room temperature. Do not freeze SIMPONI® prefilled syringe.

How long does it take SIMPONI to start working?

While individual results may vary, SIMPONI® was proven in clinical studies to: Help people with moderately to severely active UC get their symptoms under control in as few as 6 weeks. Begin to improve the appearance of the intestinal lining in as few as 6 weeks.