How does it work? Entresto reduces excess fluid in your body and relaxes blood vessels, which makes it easier for your heart to pump blood around your body. Over time it has been shown to improve ejection fraction (the measurement of your heart’s pumping function).

How does neprilysin inhibitor work?

Neprilysin inhibitors are a new class of drugs used to treat high blood pressure and heart failure. They work by blocking the action of neprilysin thus preventing the breakdown of natriuretic peptides.

How does Sacubitril and valsartan work?

Sacubitril belongs to a class of drugs called neprilysin inhibitors and valsartan belongs to a class of drugs called angiotensin receptor blockers (ARBs). They work by relaxing blood vessels so that blood can flow more easily, which makes it easier for your heart to pump blood to your body.