Mutations in the IL2RG gene cause X-linked SCID. The IL2RG gene provides instructions for making a protein that is critical for normal immune system function. This protein is necessary for the growth and maturation of developing immune system cells called lymphocytes.

What are symptoms of SCID?

• Pneumonia.
• Repeated ear infections.
• Meningitis.
• Blood infection.
• Chronic skin infections.
• Yeast infections in the mouth and diaper area.
• Diarrhea.
• Liver infection (hepatitis)

What are the types of SCID?

The most common types of typical SCID are: X-linked SCID, ADA SCID, RAG-1 or RAG-2 SCID, and IL7R SCID. X-linked SCID is caused by mutations on the X chromosome, and generally only occurs in boys.