By binding to the AT1 receptor, an ARB decreases aldosterone, vasopressin, and catecholamine release [137-142]. ARB also causes vascular vasodilation, and inhibition of sodium and water reabsorption in the kidney. Collectively, these effects lead to a reduction in blood pressure [143].

Can ARBs cause kidney failure?

We reviewed the literature along these lines and submit that ACEIs and ARBs often cause unrecognized significant worsening renal failure in CKD patients, sometimes irreversible, and that more caution is required regarding their use, especially in the older hypertensive patients, with likely ischemic hypertensive …

Can ARBs protect kidneys?

Now results from three landmark studies of almost 4,000 diabetic patients suggest that a specific class of blood pressure drugs called angiotensin receptor blockers, or ARBs, can protect kidneys and reduce the need for kidney dialysis or transplant.