Repeated frequent doses of mannitol can leach into the brain and worsen cerebral edema in the long term. Thus, mannitol is frequently recommended as a bolus spaced apart every 6 to 8 hours, limiting the number of boluses given. Mannitol can worsen renal function and precipitate renal failure.

How fast can you push mannitol?

The infusion is given as a 15% to 25% solution over a period of 3 to 5 minutes to produce a urine flow of at least 30 to 50 mL/hour. If urine flow does not increase, a second dose may be given; but if there is inadequate response, the patient should be re-evaluated.

How is mannitol given?

Mannitol I.V. (Mannitol (mannitol (mannitol injection) injection) Injection, USP) should be administered only by intravenous infusion. The total dosage, concentration and rate of administration should be governed by the nature and severity of the condition being treated, fluid requirement and urinary output.