A sterile protein substance prepared from prothrombin of bovine origin through interaction with thromboplastin in the presence of calcium; causes clotting; used as a topical hemostatic for capillary bleeding in general and plastic surgical procedures. Synonym(s): factor IIa.

What is a factor 2 mutation?

Prothrombin gene mutation (or Factor II mutation or Prothrombin G20210A) is an inherited condition that increases your predisposition to develop abnormal blood clots in the veins (deep vein thrombosis or DVT) and lungs (pulmonary embolism or PE).

What causes prothrombin deficiency?

• Lack of vitamin K (some babies are born with vitamin K deficiency)
• Severe liver disease.
• Use of medicines that prevent clotting (anticoagulants such as warfarin)