POMC is synthesized in the corticotrophs and melanotrophs of the anterior and intermediate lobes of the pituitary, respectively, as well as in peptidergic neurons in the arcuate nucleus of the hypothalamus.

Where is POMC processed?

In the anterior pituitary, POMC is processed predominantly to ACTH, β-lipotropin (LPH) and a 16 kDa N-terminal fragment.

Where is Alpha MSH produced?

Alpha-MSH, β-MSH, and γ-MSH are peptide hormones secreted from melanotropes in the pars intermedia in the pituitary. These peptides are generated from a precursor protein called proopiomelanocortin (POMC), by posttranslational proteolytic cleavage.