Senescence, the cessation of cell division and permanent withdrawal from the cell cycle, is a process that occurs throughout the lifespan — during embryogenesis, growth and development, tissue remodeling, and in wound healing.

What happens to cells during senescence?

Cellular senescence is an essentially irreversible growth arrest that occurs in response to various cellular stressors, such as telomere erosion, DNA damage, oxidative stress, and oncogenic activation, and it is thought to be an antitumor mechanism.

What are the three main points of senescence?

Types of senescence

Senescence occurs in three different scenarios: senescence due to normal aging; senescence due to age-related diseases, and senescence induced due to therapy (such as chemotherapy). Many studies have been conducted to understand senescence that happens because of natural aging.