Tetrodotoxin causes paralysis by affecting the sodium ion transport in both the central and peripheral nervous systems. A low dose of tetrodotoxin produces tingling sensations and numbness around the mouth, fingers, and toes.

How does tetrodotoxin cause muscle paralysis?

EFFECTS OF SHORT-TERM (LESS THAN 8-HOURS) EXPOSURE: Tetrodotoxin interferes with the transmission of signals from nerves to muscles by blocking sodium channels. This results in rapid weakening and paralysis of muscles, including those of the respiratory tract, which can lead to respiratory arrest and death.

Why do you experience numbness after eating pufferfish?

Westwood experienced numbness after eating the pufferfish meal because TXX causes: Motor neurons to fire continuously, overloading the brain with signals, resulting in numbness. Motor neurons to stop firing, preventing communication with the brain, resulting in numbness.