It's generally not recommended to enable large frames unless your organization have the ability to configure every device on the network. Fragmentation. When using jumbo frames routers and switches can also get bogged down fragmenting packets of different sizes.

Should I enable or disable jumbo frames?

In short, jumbo frame should only be ON or enabled when you have implemented some sort of internal network storage solution. It should be disabled where you have any sort of internet access.

Should I be using jumbo frames?

When should jumbo frames be used? Use jumbo frames only when you have a dedicated network or VLAN, and you can configure an MTU of 9000 on all equipment, to increase performance. A good example of this approach is a separate SAN or storage network.