Future Zeno has the highest kill count in the entire franchise, as he erased an entire multiverse, overall having erased 25 universes. In the case of the manga, he even went as far as to erase an entire timeline.

Can Zeno erase any universe?

It is implied in the Tournament of Power that, again if he wishes it, Zeno can erase all timeline incarnations of a universe, causing anyone in that said universe to disappear, implying that, as long as a single timeline remains unharmed, an alternate timeline version of the person will not be wiped out (Future Trunks ...

Can Zeno erase Angels?

Despite their subservient nature to the Gods of Destruction and Supreme Kais, they hold a designation above that of the gods, as Zeno spared the Angels from being erased in the Tournament of Power. Despite their power, they are bound by laws that prevent them from directly fighting threats such as Moro.