Regulation by phosphorylation is a particularly common mechanism in intracellular signalling. ... The kinase that catalyses the phosphorylation of pyruvate decarboxylase is subject to allosteric regulation by a number of small molecules, including acetyl CoA, pyruvate and ADP, as indicated in Figure 34 .

What type of regulation is phosphorylation?

For a large subset of proteins, phosphorylation is tightly associated with protein activity and is a key point of protein function regulation. Phosphorylation regulates protein function and cell signaling by causing conformational changes in the phosphorylated protein. These changes can affect the protein in two ways.

Is phosphorylation covalent regulation?

Phosphorylation is a covalent modification that controls the activity of enzymes and other proteins. Signals can be greatly amplified by this modification because one kinase has the potential to create an exponential chain effect on various target molecules.