Experts believe that acetaminophen is safe for people with high blood pressure. Very high doses of acetaminophen can cause serious liver damage. Long-term use of acetaminophen in high doses -- especially when combined with caffeine (Excedrin) or codeine (Tylenol with codeine) can cause kidney disease.

What is the best pain reliever to take if you have high blood pressure?

Over-the-counter Tylenol (generic acetaminophen) is often the best choice for people with high blood pressure, heart failure, or kidney problems. However, high doses of Tylenol can damage the liver, so take the lowest dose you can to get enough pain relief. Never take more than 4,000 milligrams (mg) a day.

Is Excedrin good for your heart?

This medication is a low dose of aspirin used to reduce the risk of having a heart attack in people who have heart disease. It is also used to reduce the risk of stroke in people who have previously had a stroke or "mini-stroke" (transient ischemic attack).