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What Is Saturable Binding?

Sarah Jenkins • • 7 min read
What Is Saturable Binding?

Saturable Binding
The binding of a ligand to a single binding site is definable by the concentration of the binding site (Bmax) and the concentration of unbound ligand at which the binding site is 50% occupied (Kd). The Kd is also known as the equilibrium dissociation constant. Its reciprocal is a measure of affinity.

What does non specific binding mean?

Nonspecific binding is binding of the assay antibodies which is not correlated with the specificity of the antibodies. Also analytes can bind non-specifically. There are two kinds of nonspecific binding which normally occurs in the lab and which can not be distinguished from each other easily.

What is ligand binding pharmacology?

Ligand binding model is an example of a PD model that works on the underpinning PD principle of a drug, eliciting its pharmacological effect at the receptor site. The pharmacological effect is produced by the drug binding to the receptor to either activate or antagonise the receptor.

Sarah Jenkins
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Sarah Jenkins

Sarah Jenkins is a veteran tech journalist with over 12 years of experience covering artificial intelligence, mobile innovations, and digital ethics. Her insights have appeared in leading technology publications worldwide.