Methamphetamine abusers typically are resistant to local anesthetics, have an increased risk of adverse events related to drug interaction and are less able to metabolize local anesthetics than the general population. These patients will require a larger than normal dose of local anesthetic, without vasoconstrictors.

What drugs interfere with anesthesia?

Street drugs

Street or 'recreational' drugs, such as heroin, LSD and cocaine, can strongly influence the anaesthetic. Cocaine and ecstasy are two drugs that excite the nervous system. They may excite your heart, producing dangerous swings in blood pressure and heart rate, both during and after the operation.

What illegal drugs should be avoided before surgery?

Do not use any illegal, recreational drugs (including cocaine, marijuana) 24 hours before surgery. Do not smoke prior to surgery. Ask your physician about nicotine replacement treatment if you wish to stop smoking.