Cefepime is also very active against Gram-positive cocci: Staphylococcus aureus (methicillin-susceptible strains only), Streptococcus pneumoniae, Streptococcus pyogenes. Some of the methicillin-resistant strains of staphylococcus are susceptible to cefepime; Enterococcus is resistant.

Does cefepime have Enterococcus coverage?

No cephalosporin covers Enterococcus (except Ceftaroline). Only Ceftazidime and Cefepime cover Pseudomonas. Only Cefoxitin and Cefotetan have good anaerobic coverage.

What antibiotic covers Enterococcus?

Ampicillin plus ceftriaxone is as effective as ampicillin plus gentamicin for treating enterococcus faecalis infective endocarditis.