Episomal iPSC Reprogramming Vectors are a cost-effective mixture of three vectors designed to provide the optimal system for generating transgene-free and virus-free induced pluripotent stem cells (iPSCs) in a feeder-free environment.

What is iPSC reprogramming?

Reprogramming somatic cells into induced pluripotent stem cells (iPSCs), which possess unique properties of self-renewal and differentiation into multiple cell lineages, is achieved by transduction using a defined set of transcription factors: Oct4 (Pou5f1), Sox2, Klf4, and c-Myc (OSKM) in mice,^1,2 and humans.

What is an example of cellular reprogramming?

For example, mouse embryonic fibroblasts or mouse pancreas-derived epithelial cells reprogrammed to iPSCs and then differentiated to functional pancreatic beta cells were capable of treating diabetes in mice (Jeon et al., 2012).