Due to the risk of precipitate formation, the use an in-line 0.22 micron filter when infusing intravenous phenytoin is highly recommended. Administration sets disconnected/reconnected from patient are replaced every 24 hours. All clinical areas.

Does Dilantin require a filter?

An in-line filter (0.22-0.55 microns) should be used. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution or container permit. The diluted infusion mixture (Dilantin plus normal saline) should not be refrigerated.

Why phenytoin must give through syringe pump?

Optimum control without clinical signs of toxicity can most often be achieved with serum levels in the range 10 - 20mg/1 (40 - 80 micromoles/1). Because of the risk of local toxicity, intravenous phenytoin should be injected slowly directly into a large vein through a large-gauge needle or intravenous catheter.