Anemia in Hypothyroidism
The low thyroid hormone levels of hypothyroidism suppress the activity of bone marrow, the tissue that makes red blood cells. That lowers the production of red blood cells and triggers anemia.
How does hypothyroidism cause anemia?
Anemia in hypothyroidism might result from bone marrow depression, decreased erythropoietin production, comorbid diseases, or concomitant iron, vitamin B12, or folate deficiency. Altered iron metabolism and oxidative stress may contribute to anemia in hyperthyroidism.
Why does hypothyroidism cause macrocytic anemia?
Anemia associated with hypothyroidism is usually normocytic or macrocytic. Because thyroid hormone stimulates the production of erythropoietin and affects hematopoiesis, a reduction in thyroid hormone production may cause anemia.
