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Where Is Pepsinogen Found?

Chloe Bennett • • 6 min read
Where Is Pepsinogen Found?

Pepsinogens are synthesized and secreted primarily by the gastric chief cells

chief cells
The gastric chief cell (also known as a zymogenic cell or peptic cell) is a cell in the stomach that releases pepsinogen and chymosin. Pepsinogen is activated into the digestive enzyme pepsin when it comes in contact with hydrochloric acid produced by gastric parietal cells.
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of the human stomach before being converted into the proteolytic enzyme pepsin, which is crucial for digestive processes in the stomach.

What is the function of pepsinogen?

A substance made by cells in the stomach. Acid in the stomach changes pepsinogen to pepsin, which breaks down proteins in food during digestion.

What gland produces pepsinogen?

Pepsinogen is secreted from peptic (or chief) cells in the oxyntic gland. Some pepsinogen is also secreted from mucosal cells in the gastric antrum and the duodenum. In the presence of gastric acid this proenzyme is converted into active pepsin, which itself catalyzes further conversion from pepsinogen.

Chloe Bennett
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Chloe Bennett

Chloe Bennett explores the intersection of pop culture, streaming entertainment, digital trends, and contemporary lifestyle. Her weekly commentary reaches thousands of culture enthusiasts.