The central nervous system (CNS) is considered to be immune-privileged tissue in which adaptive immunity and inflammation are highly controlled. This feature serves to protect post-mitotic neural cells from potential immune response-mediated injury and death.

Why is the brain immunologically privileged?

The idea that the brain was an immune privileged site was based on several factors, including the presence of the BBB, the lack of conventional draining lymphatics, a shortage of professional antigen-presenting cells (such as dendritic cells), low levels of MHC molecules, and the presence of many antiinflammatory ...

What is immunologically privileged uterus?

Immune privilege is not simply the absence of leukocytes, but involves immune and non-immune cells acting synergistically together at multiple levels to create a unique tolerogenic environment. A number of the pathways are shared by the testis and gravid uterus.