HDL is mainly secreted by the liver and small intestines. The liver, which secretes ~70–80% of the total HDL in plasma, is the main source of HDL in the circulation. Apolipoprotein (apo)AI is the major structural protein and constitutes the framework of HDL to bear phospholipids and cholesterol.

Where does good HDL come from?

Some hormones, such as estrogen or thyroid hormone, increase HDL concentrations. Exercise and moderate alcohol consumption are associated with higher HDL, too, according to research. The right food choices can lower your LDL levels, which improves your HDL to LDL ratio.

Is HDL made in the small intestine?

The intestine, along with the liver, is an important site for the synthesis and secretion of apoA-I, the principal apoprotein of HDL, and contributes approximately 50% of total plasma apoA-I (18).