As well as being bactericidal, human sebum and C6H at sublethal concentrations inhibit the production of virulence determinants and the induction of antibiotic resistance by S. aureus and other important pathogens (9). Thus, fatty acids can debilitate potentially harmful bacteria at several levels.

Does sebum have antibacterial properties?

Various sebum free fatty acids (FFAs) have shown antibacterial activity against a broad range of Gram-positive bacteria, resulting in the suggestion that they are accountable, at least partially, for the direct antimicrobial activity of the skin surface.

Does sebum kill bacteria?

Sebum serves to keep us healthy by keeping in check the growth of certain bacteria on our skin. That's because sebum contains chemicals that kill bacteria. This helps ensure bacteria don't invade into deeper layer of our skin.