In pharmacology, Schild regression analysis, named for Heinz Otto Schild, is a tool for studying the effects of agonists and antagonists on the response caused by the receptor or on ligand-receptor binding. and can be used to quantify the strength of the antagonist.

What is Schild analysis used for?

Schild analysis is a very powerful method to quantify the potency of a competitive antagonist and to test whether the blockade of response by a molecule is consistent with simple competitive antagonism.

What does a large KB value mean pharmacology?

The dose-response curve obtained in the presence of a competitive antagonist is parallel to the dose-response curve obtained in the absence of antagonist. If the Kb is small and the concentration high, the antagonist will have a more pronounced effect than if the Kb is large and the antagonist concentration is small.