Serotonin is sometimes called a “feel-good” chemical because it's associated with positive feelings of well-being. Norepinephrine is related to alertness and energy. It's believed that SNRIs help treat depression by keeping up the levels of these two chemical messengers in your brain.

What does serotonin and norepinephrine do?

2 Serotonin helps regulate mood, anxiety, and other functions and norepinephrine helps mobilize the brain for action and can improve energy and attentiveness. SNRIs have been found to be effective in treating mood disorders like depression, aspects of bipolar disorder, and anxiety disorders.

How does serotonin affect norepinephrine?

Serotonin, also called a “feel-good” hormone, improves mood and norepinephrine improves alertness and energy.