Proton pump inhibitors (PPIs) bind to enzyme H⁺/K⁺-ATPase and inhibit its activity in the stomach, thus decreasing the secretion of gastric acid. PPIs may trigger acute interstitial nephritis, a potentially severe adverse event commonly associated with acute kidney injury.

Can proton pump inhibitors cause kidney problems?

A large retrospective study found that the acid-suppressing medications increase the risk of acute kidney injury and chronic kidney disease. Individuals who take proton pump inhibitors (PPIs) are at increased risk of kidney damage, according to a large population-based study.

Are PPIs bad for kidneys?

In recent years, the use of proton pump inhibitors (PPI), especially omeprazole, has been associated with development of chronic kidney disease (CKD). These drugs are widely used worldwide. Although some studies have found an association between the use of PPI and the onset of acute renal failure and CKD.