Sudafed (Pseudoephedrine) relieves stuffy nose, but it could keep you up at night.

Can Sudafed cause insomnia?

Decongestants can come in handy when you're suffering from a stuffy nose. They can be taken as a nasal spray, like oxymetazoline (Afrin), or as an oral decongestant, like pseudoephedrine (Sudafed). But one downside is that decongestants can cause insomnia.

Is Sudafed OK before bed?

To help prevent trouble in sleeping, take the last dose of pseudoephedrine for each day a few hours before bedtime. If you have any questions about this, check with your doctor. Take this medicine only as directed.