Numerous target cells are present in this patient with hemoglobin E and beta thalassemia trait. Target cells, or codocytes, have an excess of cell membrane relative to cell volume. Macrocytic target cells can be seen in liver disease, and microcytic target cells may be seen in thalassemia.

What are target cells in the blood?

Codocytes, also known as target cells, are red blood cells that have the appearance of a shooting target with a bullseye.

What is target cell and in which condition it is found?

Target cells have excess membrane cholesterol and phospholipid and decreased cellular hemoglobin. Examples of other conditions in which target cells may be present include thalassemias, hemoglobin C disease, post splenectomy, and obstructive jaundice. ×