Platelet aggregation and clot formation is an important stage in the atherogenesis process. ... Upon activation, platelets change shape and in the presence of fibrinogen aggregate to form the platelet plug of the thrombus. Further, a more stable thrombus is formed by a fibrin mesh binding to the platelet aggregate.

What is involved in platelet aggregation?

A main adhesion molecule involved in platelet aggregation is the membrane protein, GPIIb/IIIa complex. ... Nevertheless, the receptor-bound fibrinogen acts as a bridge between two GPIIb/IIIa molecules on adjacent platelets [83]. This is the final common pathway of platelet aggregation induced by platelet chemical agonists.

What is a platelet aggregation agent?

Platelet aggregation inhibitors work in different places of the clotting cascade and prevent platelet adhesion, therefore no clot formation. Aspirin, the most commonly used antiplatelet drug changes the balance between prostacyclin (which inhibits platelet aggregation) and thromboxane (that promotes aggregation).