The imidazoles are synthetic fungicides that disrupt ergosterol biosynthesis; they are commonly used in medical applications and also in agriculture to keep seeds and harvested crops from molding.

What does imidazole treat?

An imidazole antifungal used to treat vulvovaginal candidiasis. A broad spectrum antifungal used to treat seborrheic dermatitis and fungal skin infections. A topical antifungal used to treat tinea pedis, tinea cruris, tinea corporis, cutaneous candidiasis and tinea versicolor.

What is the mechanism of action of imidazole?

Mode of Action:

Imidazoles alter the cell membrane permeability of susceptible yeasts and fungi by blocking the synthesis of ergosterol (demethylation of lanosterol is inhibited), the primary cell sterol of fungi. The enzyme targeted is a fungal cytochrome P450 (CYP450).