Fullness can begin as early as when a food or drink is consumed, and it continues as the food enters the gut to be digested and absorbed. With that process, the stomach expands to accommodate the meal, causing satiety signals in the brain to go off.

What part of the body so we get satiety from?

The hypothalamus is a region of the brain that controls satiety, or satisfaction. There are two centers of the hypothalamus: one that controls feeding and one that controls satiety. They work together to maintain feeding and satiety in balance.

What organs are involved in satiety?

The three parts of the hypothalamus that regulate food intake are called the ventromedial nuclei, the lateral hypothalamic area, and the arcuate nucleus. The ventromedial nuclei is the satiety center, and when stimulated, it causes the sensation of fullness.