No. A Greyhound fact check reveals that the USS Keeling (codenamed "Greyhound") is fictional and was not a real-life Navy destroyer. A large portion of the movie was shot aboard the USS Kidd (DD-661), a Fletcher-class Navy destroyer named after Rear Admiral Isaac C.

Did they use real ships in Greyhound?

While much of Greyhound was filmed in Baton Rouge, Louisiana, several real Naval ships were used during both preproduction and principal photography. ... In March of the same year, photography also took place on the USS Kidd Naval destroyer in Baton Rouge.

Did Greyhound sink GREY Wolf?

After a harrowing couple of days crossing the Atlantic Ocean, the USS Keeling (going by the call sign Greyhound,) survives its battle against several German U-Boats. Most notably, Captain Ernest Krause (Hanks) bests the sub known as “The Grey Wolf,” as Greyhound squares up and blasts it out of the water.