In addition, lithium is used as monotherapy to treat acute episodes of unipolar depression and as maintenance treatment to prevent recurrence of unipolar depressive episodes. Lithium was first used by psychiatrists in the mid-1800s [2]. The first controlled trial of lithium for unipolar depression was in 1968.

What is the best treatment for unipolar?

Efficacy of antidepressants plus psychotherapy — For the initial treatment of unipolar major depression, randomized trials indicate that the combination of pharmacotherapy and psychotherapy (eg, cognitive-behavioral therapy or interpersonal psychotherapy) is more efficacious than either pharmacotherapy alone or ...

How long does it take for lithium to work for unipolar depression?

Depression and quality of life scores started to improve quickly within the following month. Two months after introduction of lithium, full remission was reported. This state was maintained for 12 months and enabled the patient to return to work.