So here's the big takeaway: There's no evidence that a short-term boost in hand-washing and cleaning will reduce your body's immune function.
What does over cleaning do to your immune system?
According to the “hygiene hypothesis,” being too clean can cause allergies, asthma and other health problems. This hygiene theory says immunity is learned when people's immune systems are exposed to environmental triggers.
Can being too clean make you sick?
Too much cleanliness may be causing us to develop allergies, asthma, inflammatory bowel diseases, and other autoimmune disorders.