Macrophages are constituents of the reticuloendothelial system (or mononuclear phagocyte system) and occur in almost all tissues of the body. In some instances, macrophages are fixed in one place within tissues, such as in the lymph nodes and the intestinal tract.

Where can you find macrophages?

Macrophages can then be found in many areas in the body, like different tissues, lungs, skin, and also organs of the immune system like the spleen, lymph nodes, and bone marrow.

Are macrophages found in tissue?

Macrophages are distributed in tissues throughout the body and contribute to both homeostasis and disease. Recently, it has become evident that most adult tissue macrophages originate during embryonic development and not from circulating monocytes.