Soreness tends to feel better with movement, so there may not be a need to take a day off. Just keep your mileage light and pace easy. The first minutes or even miles of a run may feel achy, but it should get better as you keep going. Pain is much more serious and can manifest in different ways.
Is it OK to run with sore muscles?
The good news is that once your muscles repair themselves and grow stronger, they are more resistant to damage for up to eight weeks. While it's okay to do an easy run while you're dealing with DOMS, hold off on doing another intense workout for a few days. And expect to feel a little stiff during the first mile or so.
Should I still jog if my legs are sore?
Answer: If you're beginning a workout program, your legs may be sore from new stress. If running is part of your first week's plan, it's fine to work through the soreness; but if you're still hurting after a week, stop running. Instead, rest more between workouts.