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Why Are Tocolytics Contraindicated in Pprom?

Marcus Vance • • 6 min read
Why Are Tocolytics Contraindicated in Pprom?

Prophylactic tocolysis begun before the onset of labor increases the likelihood of delaying the onset of labor for 1-2 days, but not beyond. Aggressive long-term tocolysis may increase the maternal risk of chorioamnionitis

chorioamnionitis
Multiple studies have reported risk factors for chorioamnionitis, including longer duration of membrane rupture, prolonged labor, nulliparity, African American ethnicity, internal monitoring of labor, multiple vaginal exams, meconium-stained amniotic fluid, smoking, alcohol or drug abuse, immune-compromised states, ...
and endometritis.

Can you give Tocolytics in Pprom?

In women with preterm premature rupture of membranes (PPROM), the use of tocolysis is still controversial. In theory, tocolysis may prolong pregnancy in women with PPROM, thereby allowing for the corticosteroid benefit and reducing the morbidity and mortality associated with prematurity.

When should you not use Tocolytics?

Who should not use tocolytic medications?
  1. mild preeclampsia.
  2. relatively stable bleeding during the second or third trimester.
  3. serious medical conditions.
  4. a cervix that has already dilated 4 to 6 centimeters or more.
Marcus Vance
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Marcus Vance

Marcus Vance is a cybersecurity auditor and technology writer dedicated to educating the public about online safety, data privacy regulations, enterprise security, and emerging cyber threats.