After briefly pushing her away, Andrew apologized, and he eventually became the first person Meredith said "I love you" to since Derek. However, his fears over not being "enough" for a surgical legend kept cropping up throughout their cases and through Meredith's insurance fraud case, which ultimately led to a breakup.

Why do Meredith and Derek break up in Season 4?

Relationships. Meredith and Derek are no longer a couple but sleep together often. Derek wants more, but Meredith can't give that to him and they stop sleeping together.

What seasons do Meredith and Derek break up?

Meredith and Derek eventually break up again, and Derek briefly dates Nurse Rose. The former couple remain professional as they run a clinical trial together.