Damage to other parts of the brain as well as changes in brain chemicals linked to depression and hyper moods (mania) could also play a role. An injury or disease that affects your brain can lead to pseudobulbar affect. Other brain conditions commonly linked to PBA include: Alzheimer's disease.

Can depression cause pseudobulbar affect?

But depression is common among those who have pseudobulbar affect.

What can trigger PBA?

What causes PBA? Brain damage from a stroke, brain tumor, or head trauma can lead to PBA. PBA can also happen along with such conditions as multiple sclerosis, Parkinson's disease, Alzheimer's disease, ALS and dementia. Normally, the "feel" and "express" parts of your brain work together.