Thrombin is an unique molecule that functions both as a procoagulant and anticoagulant. In its procoagulant role it activates platelets through its receptor on the platelets. It regulates its own generation by activating coagulation factors V, VIII and even XI resulting in a burst of thrombin formation.

Why is thrombin important in blood clotting?

Thrombin is an endogenous protein involved in the coagulation cascade, where it has a key role in the formation of fibrin clots by converting fibrinogen to fibrin.

What is the role of thrombin in Haemostasis?

The central role of thrombin in hemostasis. ... During this process, the serine proteinase, thrombin, is generated both locally and rapidly at sites of vessel damage. It plays a pivotal role in clot promotion and inhibition, and cell signaling, as well as additional processes that influence fibrinolysis and inflammation.