Beyond this initial buffering, lactic acid appears to be buffered almost entirely by the bicarbonate buffer system.

How does lactate get buffered?

According to this model (solid arrows), lactic acid is buffered in the muscle by plasma bicarbonate entering the cell in exchange with lactate through an antiport carrier mechanism (hatched box); plasma standard bicarbonate decreases in an almost 1:1 ratio with the increase in plasma lactate concentration, while lactic ...

What is the best buffer of lactic acid in our body?

Best known as baking soda, sodium bicarbonate is also the most abundant acid buffer in muscle tissue.