Antipsychotics block dopamine, which is what causes the extrapyramidal side effects in the first place. Anticholinergics increase dopamine so it becomes leveled out in your system.
Why do antipsychotics cause EPS?
Antipsychotics help improve symptoms by binding to dopamine receptors in your central nervous system and blocking dopamine. This may prevent the basal ganglia from getting enough dopamine. Extrapyramidal symptoms can develop as a result.
Why do atypical antipsychotics cause less EPS?
Atypical antipsychotic drugs (APDs) have been hypothesized to show reduced extrapyramidal side effects (EPS) due to their rapid dissociation from the dopamine D2 receptor.
