Although bitters most likely won't go bad before you're through with your bottle, their flavor and aromatics tend to break down over time. ... Fruit bitters tend to have “refrigerate after opening” written somewhere on the bottle, implying that there is some sort of shelf life to their bottles.

Do bitters ever expire?

Bitters typically do not have an expiration date. Because of this, most bitters have a shelf life comparable to any spirit: essentially indefinite. ... As a liqueur, bitters have a high alcohol content that might surprise you: Angostura, the most famous brand of bitters, has a whopping 45% abv in that little bottle.

Do bitters have to be refrigerated after opening?

You don't need to keep Angostura Bitters refrigerated after opening the bottle. There is no expiration after opening the bottle.