It may sound unfair to even bring it up, but magic stops for no man – only those who can respond with spells of their own. Some have hypothesized that of all the superheroes to fall prostrate before the powers of magic, Superman is the most vulnerable. That's why Shazam has humbled Superman on multiple occasions.
Who can easily kill Superman?
There's no doubt The Flash can outrun Superman. In all of their races since 1967's Superman #199, Barry has won twice. However, when the challenge is for charity, he takes it easy on Clark. Needless to say, Flash has the power to defeat Superman.
What can kills Superman?
Green kryptonite weakens Superman and other Kryptonians. It can and will kill them with long-term exposure. Kryptonians under green kryptonite's effects experience severe muscular weakness, usually to the point of collapse, and excruciating pain, with both conditions progressively intensifying.