Experts say that for up to 25% of people, most antidepressant medications -- including the popular SSRI (selective serotonin reuptake inhibitor) drugs like Lexapro, Paxil, Prozac, and Zoloft -- can cause a weight gain of 10 pounds or more.

Why am I gaining so much weight on Prozac?

Antidepressant-induced weight gain is tied to appetite changes. “With medications for depression, increases in appetite occur. Generally, then, anything becomes a little bit more appetizing — and our cravings usually don't fall under fruits and vegetables,” Cabrero points out.

Does Prozac make it hard to lose weight?

As an SSRI, Prozac increases the levels of serotonin in the brain and these are generally the first-line treatment for depression. Any weight loss you may experience while taking Prozac may only be temporary and weight gain after the first few months may be possible.